Making use of single-molecule optical and AFM imaging and drive-spectroscopy approaches, we seek out to unravel the mechanistic elements of the composition and dynamics of chromosomes. Our exploration interests involve:
Human Rad51 filaments on double- and solitary-stranded DNA: correlating normal and irregular varieties with recombination function.
Dynamics of initiation, termination and reinitiation of DNA translocation via the motor protein EcoR124I
Our function was rapidly followed up by Other individuals, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 revealed their results on transistors made out of solitary- and multi-walled carbon nanotubes in Utilized Physics Letters.
This yielded a breakthrough. In just a few months, we had been capable of evaluate transport by an individual one-walled carbon nanotube. According to small-temperature experiments by an excellent PhD university student in my group, Sander Tans (now a valued colleague and professor at Delft College of Technological innovation with an Energetic investigate lab at AMOLF in Amsterdam), we showed that carbon nanotubes ended up genuine quantum wires with incredibly extended (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic behaviour.
Microbiology has only existed for your century, considering the fact that we started to study micro-organisms much more very seriously. I assumed nanobiology was an appropriate term, simply because all molecular biological related interactions take place on the nanoscale: a protein is several nanometres in measurement, DNA is 2 nm thick.’
A lot of linked developments adopted, wherever our team founded distinctive transistor variants such as one-electron transistors at room temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled multiple transistors into small proof-of-basic principle Digital circuits.
Example (one) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim with the pore is highlighted in red, in addition to a 3D rendering in the movement from the DNA rod is exhibited.
Imagine if, in place of making use of regular best-down silicon electronics, transistors could ceesdekker be created from the bottom up employing single organic and natural molecules because the switching things? This idea, which grew to become the basis of nowadays’s field of molecular electronics, 1st emerged within the seventies.
It had been all through this era that Dekker performed research on magnetic spin methods and on sound in superconductors and semiconductors.
An built-in microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes
1999, to start with measurement in the wavefunction of one molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for your new Luttinger description of interacting electrons in nanotubes
2005, discovery of your mechanism of DNA uncoiling by topoisomerase enzymes; discovery of very long-variety conformational variations in Mre11/DNA fix complexes; and to start with power measurements over a DNA molecule in a nanopore
‘I am driven by speculate and thoughts. On a material degree I uncover solutions in physics, but I working experience my deepest happiness with God. That faith also drives my science And the way I handle persons.