Spatial framework facilitates cooperation inside of a social Predicament: empirical proof from the bacterial Group
Our group studies bacterial mobile division which is aiming to constitute a ‘bottom up biology’ in artificial cells that could autonomously divide. Our principal interest lies in mobile division, chromatin construction, and spatial Management.
, Groningen researchers present the results of their efforts to produce labs a lot more sustainable and supply tricks for other labs.
Our do the job was quickly adopted up by others, most notably by Phaedon Avouris and colleagues at IBM, who in Oct 1998 published their conclusions on transistors made from one- and multi-walled carbon nanotubes in Used Physics Letters.
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and to start with at any time research of your dynamics DNA supercoils and the discovery of supercoil hopping
The coiled-coil of your human Rad50 DNA mend protein consists of unique segments of enhanced flexibility
You're a Christian. If you could potentially make such a artificial mobile, would you be 1 phase nearer to God, or would the role of God have diminished considerably all over again?
Circulation-driven rotary motors including windmills and water wheels generate practical processes in human Modern society. Whilst examples of such rotary motors also characteristic prominently in mobile biology, cees dekker their artificial development at the nanoscale has remained difficult. Listed here we show circulation-pushed rotary motion of a self-organized DNA nanostructure that's docked on to a nanopore in a skinny solid-condition membrane. An elastic DNA bundle self-assembles right into a chiral conformation on phoretic docking on to the stable-point out nanopore, and subsequently shows a sustained unidirectional rotary motion of up to 20 rev s−one.
The rotors harness Vitality from a nanoscale h2o and ion circulation that's created by a static chemical or electrochemical likely gradient inside the nanopore, which are founded by way of a salt gradient or applied voltage, respectively. These synthetic nanoengines self-Arrange and work autonomously in physiological problems, suggesting approaches to developing Strength-transducing motors at nanoscale interfaces.
Resolving the phase sizing in condensin-driven DNA loop extrusion identifies ATP binding as the phase-generating course of action
An built-in microfluidic System for quantifying drug permeation across biomimetic vesicle membranes
1999, 1st measurement from the wavefunction of solitary molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof for any new Luttinger description of interacting electrons in nanotubes
For example, we think about the nucleopore advanced, a gateway among the cell nucleus as well as cytoplasm. This is an extremely difficult system and as a consequence tough to research inside of a mobile, so we use biomimetics. We reconstruct holes and after that insert individual things in the nucleopore complex to review transport by it at the single-molecule amount.’
It absolutely was an extremely appealing time, throughout which I acquired loads of assistance from Delft University of Know-how, where I was a professor at time, And that i begun several collaborations with molecular biologists. That assisted me understand quite a bit.’